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Xray Crystallography
Xray Crystallography is a powerful technique for solving high resolution three dimensional protein structures. Nexomics Biosciences has extensive experience solving native protein, protein-protein, and protein-nucleic acid complexes using x-ray crystallography. We also offer a number of services geared toward producing diffraction crystals. Our service offering include but are not limited to the following:

  • Crystal Screening
    •     HTP screening under 1536 conditions
    •     Manual screening using standard kit analysis
  • Crystal Optimization
  • Crystal Data Collection
  • Crystal Protein Structure Determination

Nuclear Magnetic Resonance
Nuclear Magnetic Resonance (NMR) is a technique for solving protein and nucleic acid stuctures as well as evaluating dynamics. Nexomics Biosciences has deep experience with NMR structural biology techniques. We offer a full range of services from data collection, data processing, data analysis and structure determination. Our service offering include but are not limited to the following:

  • NMR Data collection
    •     500 MHz Varian
    •     600 MHz (cryoprobe) Bruker
    •     600 MHz (cryoprobe) Varian
    •     800 MHz Bruker
  • Biophysical analysis
    •     Dynamics, disorder, stability
  • NMR Spectral Analysis
    •     Backbone Assignments
    •     Sidechain assignment
    •     Protein-Protein , Protein / Nucleic Acid complex analysis
    •     Chemical shift pertubation studies / Xfiltered NOESY anaylsis
    •     NMR Protein Structure Determination