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1D / 2D NMR can be used to assess sample quality, purity and stability.
NMR screening can be used to identify interacting ligands and protein partners.
Rotational Correlation Time Measurements
Rotational correlation time is the time it takes a molecule to rotate one radian.
Application includes: estimation of molecular weight (e.g., oligomerization), and more recently has been used to detect presence of antigen in sample in liquid biopsy.
Small Molecule Screening
NMR can used to detect small molecule interactions with target proteins using either saturation transfer difference (STD), WaterLogsy, or protein-detected chemical shift perturbation studies. Using a micro NMR probe (30 uL sample volume) and automated NMR sample changer, ligand screeing can be done in high throughput.
Protein NMR Resonance Assignments
The process of correlating NMR chemical shifts to specific atoms in a protein or other biomolecule. Resonance assignments enable analysis of protein structure and dynamics, as well as studies of ligand binding.
Protein Dynamics Studies
NMR can be used to give insights into protein dynamics, entropic changes due to complex formation, and allosteric effects associated with ligand binding.
Protein Interaction Studies
Chemical shift perturbation and/or X-filtered NOESY experiments can be used to detect protein-protein, or protein-ligand interactions.
Nucleic Acid NMR
NMR can be used to probe nucleic acid structure and interactions.